Cognitive impairment in temporal lobe epilepsy: role of online and offline processing of single cell information.

Cognitive impairment is a common comorbidity in temporal lobe epilepsy (TLE) and is often considered more detrimental to quality of life than seizures. While it has been previously shown that the encoding of memory during behavior is impaired in the pilocarpine model of TLE in rats, how this information is consolidated during the subsequent sleep period remains unknown. In this study, we first report marked deficits in spatial memory performance and severe cell loss in the CA1 layer of the hippocampus lower spatial coherence of firing in TLE rats. We then present the first evidence that the reactivation of behavior-driven patterns of activity of CA1 place cells in the hippocampus is intact in TLE rats. Using a template-matching method, we discovered that real-time (3-5 s) reactivation structure was intact in TLE rats. Furthermore, we estimated the entropy rate of short time scale (∼250 ms) bursting activity using block entropies and found that significant, extended temporal correlations exist in both TLE and control rats. Fitting a first-order Markov Chain model to these bursting time series, we found that long sequences derived from behavior were significantly enriched in the Markov model over corresponding models fit on randomized data confirming the presence of replay in shorter time scales. We propose that the persistent consolidation of poor spatial information in both real time and during bursting activity may contribute to memory impairments in TLE rats.

Changes in indications for endoscopic sinonasal surgery over 14 years.

OBJECTIVE: To assess how surgical indications for endoscopic sinonasal surgery have changed over time. MATERIAL AND METHODS: The surgical indications of 1173 patients who underwent endoscopic sinonasal surgery between 1994 and 2007 were reviewed retrospectively. RESULTS: Preoperative diagnoses were chronic sinusitis without nasal polyps in 511 patients (43.6%), chronic sinusitis with nasal polyps in 434 (36.9%), concha bullosa in 113 (9.6%), nasal mass in 66 (5.6%), and others in 49 patients (4.1%). Over 60% of patients had surgery for chronic sinusitis without nasal polyps between 1994 and 1999, whereas nearly 60% of patients who underwent surgery between 2001 and 2007 had chronic sinusitis with nasal polyps. CONCLUSIONS: Reasons for the decrease in the number of the patients with chronic sinusitis without nasal polyps and the increase in the number of patients with chronic sinusitis with nasal polyps might include: 1) Administration of maximal medical therapy; 2) Increased recognition of the possibility for false positive opacifications in computed tomography and increased understanding that not all anatomical variations predispose to sinusitis; 3) More careful "profit and loss" discussions with patients as our postoperative experience increased; 4) More patients with nasal polyps underwent endoscopic sinonasal surgery as surgical skills improved, and recurrences remained common.

Radiofrequency excision of a large postcricoid mucous cyst.

OBJECTIVES: To present the case of a patient with a large mucous cyst originating from the postcricoid region that was removed by radiofrequency excision. METHODOLOGY: A 75-year-old male who complained of progressive difficulty in breathing, dysphonia, and throat discomfort upon swallowing presented at our clinic. Computerized tomography imaging showed a 4 x 4 x 3 cm cystic mass in the hypopharyngeal region. The patient had been on medical therapy for rheumatoid arthritis for 25 years, and his ability to extend his neck was totally restricted. Thus, the Kleinsasser operating laryngoscope could not be inserted; instead, the blade of a flexible intubation laryngoscope and a 30 degree rigid nasal endoscope was used to visualize the lesion. RESULT: The walls of the cyst were excised from the postcricoid region using a radiofrequency device to avoid bleeding. CONCLUSION: Radiosurgery of these kinds of lesions produces less hemorrhage and may provide a suitable alternative to classical surgery.

Primary hydatid cyst of the neck: a case report.

Hydatid cysts in the neck are quite rare, even in areas where the disease is endemic. The role of radiological investigation is important and, in these cases, the involvement of other organs should be investigated. The cyst should be excised as a whole, without being ruptured, to prevent any treatment complications. This paper presents a case of an isolated hydatid cyst localised in the supraclavicular region without any pulmonary or hepatic involvement.

Bilateral antrochoanal polyps in an adult: a case report.

Antrochoanal polyps (ACP) are almost always unilateral. Only two bilateral cases have been reported to date, both of them in children. There have been no investigations of the aetiology of the bilateral occurrence of these lesions, possibly due to the rarity of bilateral ACPs. In this paper, we report on the first adult case of bilateral ACPs and review the literature.

An unrecognized foreign body in the parotid gland after trauma.

OBJECTIVE: Foreign bodies within the parotid gland retained after trauma are rarely observed, due in part to ease of detection. Few, however, particularly wooden foreign bodies, may not be identified clinically and radiologically. CASE: A 44-year-old male was admitted complaining of recurrent swelling and pain in the left parotid gland with recent history of penetrating parotid trauma and foreign body removal. Ultrasonography revealed a high degree of parenchymal heterogeneity and an 18 x 5.7 mm linear mass shadow. Following superficial parotidectomy, an approximately 1 x 2 cm wooden fragment that was buried in the masseter muscle and surrounded by granulation tissue was palpated and extracted. CONCLUSION: Any suspicion of a residual foreign body after penetrating parotid gland trauma can be clarified with a detailed radiological examination, which may provide further guidance for treatment. The treatment modality of parotid foreign bodies is early surgical exploration, and in delayed cases, superficial parotidectomy may be needed.

A new dosage regimen for topical application of ciprofloxacin in the management of chronic suppurative otitis media.

The clinical and bacteriologic efficacy of topically applied ciprofloxacin was studied in 60 patients with chronic suppurative otitis media. Two hundred fifty and 125 microg/ml concentrations of ciprofloxacin solutions were given to two groups of patients. The duration of therapy was determined according to the clinical cure at follow-up. More than 21 days of therapy was not needed in any patient. The clinical cure rate with 250 microg/ml ciprofloxacin was 78.1% at 14 days and with 125 microg/ml it was 83.3%. However, a 100% clinical cure rate and complete bacteriologic eradication was obtained in 21 days in both groups. In each group only one patient had otomycosis by the fourteenth day of therapy, although ear discharge had ceased. It was concluded that 125 microg/ml ciprofloxacin could be applied as successfully as 250 microg/ml, and the duration of therapy had to be at least 14 days. This new dosage regimen can be adopted as an optimal dosage for ototopical application of ciprofloxacin in chronic suppurative otitis media. It will also obviously decrease the expense of therapy.

Myringoplasty in children: factors influencing surgical outcome.

Age, size, and site of perforation, condition of the ear, status of the contralateral ear, grafting materials, and more are considered factors influencing the success rates in myringoplasties in children. The ambivalence in results is mainly due to nonhomogeneous patient groups. In an effort to compose groups as homogeneous as possible for analysis of influencing factors, a retrospective study of 51 pediatric myringoplasty cases (51 ears) was undertaken. All patients had perforations caused by simple chronic otitis media. The overall surgical success rate was 82.3% at 18 months, and for young (5 to 10 years) and older (11 to 16 years) children it was 77.2% and 86.2%, respectively. Anterior, central, and total perforations healed without significant differences. Outcome in unilateral perforations was better than bilateral: 96.9% and 55%, respectively (p < 0.01). Discharging ears (100%) healed better compared with dry ears (75%) (p < 0.05). Analysis of the literature also revealed significant difference in success rates of discharging and dry ears: 92.5% and 80.6%, respectively (p < 0.01). We conclude that, contrary to comments in the literature, discharging ears in children favor good outcome and they should be operated on regardless of age and site of perforation. However, in bilateral perforations results may not be so rewarding.

Morphometric evaluation of the infralabyrinthine approach to the internal auditory canal.

Morphometric evaluation of the infralabyrinthine approach to the internal auditory canal (IAC) was performed using 20 fresh human temporal bones in order to assess the exposure limitations, inherent risks and technical difficulties that may arise due to common anatomic variations of this region. While performing the infralabyrinthine approach to the IAC, minor problems such as an anteriorly placed sigmoid sinus were easily managed. However, in 50% of the specimens, this approach was limited due to variations of the jugular bulb, restricting access to the IAC. Sacrificing the endolymphatic duct in these specimens did not significantly improve the surgical access to the eighth nerve. Furthermore, it was noted that this approach puts the facial nerve and cochlea under the risk of inadvertent damage during drilling. The authors conclude that vestibular nerve sectioning using the infralabyrinthine approach may be performed only in few selected cases and extreme care is needed in order not to damage the structures that limit this approach.